The mission of the Sampognaro Lab is fundamentally driven by the urgent, unmet need for effective therapeutic interventions against devastating neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). These debilitating conditions progressively strip individuals of their cognitive and motor functions, representing a profound challenge to global health.
Our laboratory is dedicated to pioneering research aimed at understanding the root cellular dysfunctions that contribute to disease onset and progression, with a particular focus on critical protein quality control and clearance mechanisms essential for neuronal health.
